Influence of Placenta Cryoextract on the Liver Metabolic and Functional State in Case of D-Galactosamine Hepatitis

Background. Viral hepatitis is one of the most common and dangerous diseases in world third infectious disease. The development new, more effective safer hepatoprotective drugs an urgent task biomedicine. A wide range proven biological properties cryoextract human placenta, particular presence antioxidant, immunomodulating anti-inflammatory effects, suggests that it has a effect. model D-galactosamine toxic hepatitis, which similar to viral terms morphological biochemical changes liver, was chosen for study. Objective. We are aimed study effect therapeutic preventive administration cryopreserved placenta extract on metabolic functional state liver rats. Methods. conducted 28 male rats weighing 200–220 g. Hepatitis simulated by single intraperitoneal injection 20% aqueous solution at dose 400 mg/kg. administered treatment-prophylactic mode – 1 time per day 3 days before another 2 after aminosugar (5 administrations total). Results. experimental leads formation disorders form activation lipid peroxidation processes, violation pigment metabolism, decrease protein-synthesizing function cytolytic syndrome, were indicated increase (p < 0.001) level reactants with thiobarbituric acid homogenates 2.2 times, total bilirubin 2.5 albumin-globulin ratio 46.8% alanine-aminotransferases times aspartate-aminotransferases 70.3% compared values ??of intact animals. Against background decreased 43.8%, 2.4 45.3%; protein increased 0.01) 17.4%, 53.5% indicators untreated Conclusions. Administration normalized processes restored its due antioxidant membrane-stabilizing weakened syndrome caused liver. In addition, specified neutralized D-galactosamine-induced hyperbilirubinemia.